Showing posts with label single. Show all posts
Showing posts with label single. Show all posts
Friday, 25 July 2008
Wednesday, 16 July 2008
Avastin - Wet Macular Degeneration: by Donald Arson
Avastin is the brand name for Bevaciumab a monoclonal antibody or an antibody that is an identical clone of a single parent cell. It was approved in 2004 by the FDA for use in the treatment of some cancers and is used as a first or second line treatment for patients.
As the first clinically available angiogenesis inhibitor the United States it inhibits new cancer cells by blocking the growth of blood vessels in pre-existing tumors. A solid, non-liquid, tumor needs to grow additional blood vessels to be able to reach a certain size.
With an angiostatic agent such as Avastin the growth of new blood vessels is slowed stopping the cancer from growing indefinitely. It is usually given every 14 days intravenously in the arm and can be used with other drugs in combination and with intravenous 5-fluorouracilâ€"based chemotherapy.
Developed by Genentech (NYSE: DNA), a leading biotechnology corporation, it is marketed in the United States under the Genentech name and outside the US under Roche.
When it was originally available in 2004 it was only FDA approved for the treatment of many forms of small cell lung cancer and metastatic colon cancer. A metastatic cancer, in this case colon cancer, is a cancer that spreads from one part or organ to another non-adjacent part or organ.
In 2008 the FDA opened up the doors and allowed for the treatment of breast cancer. There are also clinical trials under way to use Avastin for the treatment of non-metastatic colon cancer, metastatic renal cell carcinoma, metastatic breast cancer, metastatic glioblastoma multiform, metastatic hormone-refractory prostate cancer, metastatic or unresectable locally advanced pancreatic cancer, and metastatic ovarian cancer.
Avastin is also currently being used off-label, the practice of prescribing drugs for a purpose outside the scope of the drug's approved label, for the treatment of wet macular degeneration by some retinal specialists.
Wet macular degeneration or AMD is a condition that causes loss of vision from the growth of abnormal blood vessel choriocapillaries, through Bruch's membrane. This eventually leads to blood and protein leaking below the macula, an oval spot near the middle of the retina in the human eye. With AMD rapid, often irreversible vision loss can occur through the leaking, bleeding and scaring of the blood vessels if left untreated.
Dr. Philip J Rosenfeld, MD, PhD of the Bascom Palmer Eye Institute conducted a study that showed positive results for the treatment of AMD with Avastin. According to Dr. Rosenfeld’s study Avastin improved vision in as little as one week for patients treated for AMD.
For AMD treatment Avastin is used in very low amounts by retinal specialists. They usually have a pharmacists transfer the drug from the original vile to a pre-filled needles containing single doses. The specialists will then usually treat the patient in their own office.
As with any drug it is always best to talk to your doctor or pharmacist before starting any treatment
As the first clinically available angiogenesis inhibitor the United States it inhibits new cancer cells by blocking the growth of blood vessels in pre-existing tumors. A solid, non-liquid, tumor needs to grow additional blood vessels to be able to reach a certain size.
With an angiostatic agent such as Avastin the growth of new blood vessels is slowed stopping the cancer from growing indefinitely. It is usually given every 14 days intravenously in the arm and can be used with other drugs in combination and with intravenous 5-fluorouracilâ€"based chemotherapy.
Developed by Genentech (NYSE: DNA), a leading biotechnology corporation, it is marketed in the United States under the Genentech name and outside the US under Roche.
When it was originally available in 2004 it was only FDA approved for the treatment of many forms of small cell lung cancer and metastatic colon cancer. A metastatic cancer, in this case colon cancer, is a cancer that spreads from one part or organ to another non-adjacent part or organ.
In 2008 the FDA opened up the doors and allowed for the treatment of breast cancer. There are also clinical trials under way to use Avastin for the treatment of non-metastatic colon cancer, metastatic renal cell carcinoma, metastatic breast cancer, metastatic glioblastoma multiform, metastatic hormone-refractory prostate cancer, metastatic or unresectable locally advanced pancreatic cancer, and metastatic ovarian cancer.
Avastin is also currently being used off-label, the practice of prescribing drugs for a purpose outside the scope of the drug's approved label, for the treatment of wet macular degeneration by some retinal specialists.
Wet macular degeneration or AMD is a condition that causes loss of vision from the growth of abnormal blood vessel choriocapillaries, through Bruch's membrane. This eventually leads to blood and protein leaking below the macula, an oval spot near the middle of the retina in the human eye. With AMD rapid, often irreversible vision loss can occur through the leaking, bleeding and scaring of the blood vessels if left untreated.
Dr. Philip J Rosenfeld, MD, PhD of the Bascom Palmer Eye Institute conducted a study that showed positive results for the treatment of AMD with Avastin. According to Dr. Rosenfeld’s study Avastin improved vision in as little as one week for patients treated for AMD.
For AMD treatment Avastin is used in very low amounts by retinal specialists. They usually have a pharmacists transfer the drug from the original vile to a pre-filled needles containing single doses. The specialists will then usually treat the patient in their own office.
As with any drug it is always best to talk to your doctor or pharmacist before starting any treatment
The Life Story of Leona Lewis by Juliet Monkish
Born on 3rd April in the year 1985, Leona Louise Lewis is an English singer-songwriter and winner of the third series of the popular TV talent show "The X Factor".
Her father, Aural Josiah was an Afro-Caribbean youth worker and her mother, Marie Lewis was a social worker of Anglo-Welsh descent. The whole family grew up in Highbury and Leona went to school at Ambler Primary School in Finsbury Park. Leona was very fond of music and when she was five years old, her parents fulfilled her wish by sending her to Sylvia Young Theatre School, despite the fact that it was an expensive institution.
After Leona Lewis left school, she did all kinds of odd jobs to get into a recording studio. She was a waitress at Pizza Hut and also worked as a receptionist for Metropolitan Mortgages in Median Road, Lower Clapton, Hackney. In Stoke Newington High Street, she was also a receptionist for Head and Short Chiropodists.
By the time she was fifteen years old, she recorded a version of Minnie Riperton's "Loving You" with music producer Marley J Wills. Subsequently, Leona and Wills were invited to United States by Sony. Wills was full of praise for Leona and said that even though she was young and innocent, she had a very good voice.
In the year 2006, Leona auditioned for the third series of the X Factor. She sang "Over the Rainbow". On 16th December 2006, she was announced the winner and won a £1 million recording contract. Her mentor was Simon Cowell who participated in many training montages with her.
On a show held in 28th October, Leona lewis sang "Summertime". Simon Cowell was blown away by her performance saying that she was the best contestant he came across any of these shows.
On December 2006, her debut single "A Moment like This" was released. It was downloaded fifty thousand times within thirty minutes breaking a world record.
On 16th January 2007, the 2007 Brits award short listed Leona lewis's single "A Moment like This". It got through the second round but was eliminated and hence did not make it to the final selection. However, in the same year on May, it was awarded the prestigious Ivor Novello Award for Best Selling British Single.
On 15th March 2007, Leona lewis performed in front of Prince Charles at the UK finals of The Prince's Trust RBS Celebrate Success awards at the Barbican Centre in London. She was presented the award for "Young Achiever of the Year" and also sang "Over the Rainbow".
Nowadays, Leona lewis lives in Hackney with her boyfriend, Lou Al-Chamaa, who is an electrician by profession. They grew up in the same street and have known each other since Leona lewis was nine years old. Based on reports, they have rented a £120,000 flat together in North London and have exchanged commitment rings. Leona lewis has stated that she has made plans to marry Lou Al-Chamaa in the near future. Since she was 12 years old, Leona lewis has been a vegetarian and in the year 2008, she won PETA's Sexiest Vegetarian with Anthony Kiedis, the frontman for Red Hot Chili Peppers.
Her father, Aural Josiah was an Afro-Caribbean youth worker and her mother, Marie Lewis was a social worker of Anglo-Welsh descent. The whole family grew up in Highbury and Leona went to school at Ambler Primary School in Finsbury Park. Leona was very fond of music and when she was five years old, her parents fulfilled her wish by sending her to Sylvia Young Theatre School, despite the fact that it was an expensive institution.
After Leona Lewis left school, she did all kinds of odd jobs to get into a recording studio. She was a waitress at Pizza Hut and also worked as a receptionist for Metropolitan Mortgages in Median Road, Lower Clapton, Hackney. In Stoke Newington High Street, she was also a receptionist for Head and Short Chiropodists.
By the time she was fifteen years old, she recorded a version of Minnie Riperton's "Loving You" with music producer Marley J Wills. Subsequently, Leona and Wills were invited to United States by Sony. Wills was full of praise for Leona and said that even though she was young and innocent, she had a very good voice.
In the year 2006, Leona auditioned for the third series of the X Factor. She sang "Over the Rainbow". On 16th December 2006, she was announced the winner and won a £1 million recording contract. Her mentor was Simon Cowell who participated in many training montages with her.
On a show held in 28th October, Leona lewis sang "Summertime". Simon Cowell was blown away by her performance saying that she was the best contestant he came across any of these shows.
On December 2006, her debut single "A Moment like This" was released. It was downloaded fifty thousand times within thirty minutes breaking a world record.
On 16th January 2007, the 2007 Brits award short listed Leona lewis's single "A Moment like This". It got through the second round but was eliminated and hence did not make it to the final selection. However, in the same year on May, it was awarded the prestigious Ivor Novello Award for Best Selling British Single.
On 15th March 2007, Leona lewis performed in front of Prince Charles at the UK finals of The Prince's Trust RBS Celebrate Success awards at the Barbican Centre in London. She was presented the award for "Young Achiever of the Year" and also sang "Over the Rainbow".
Nowadays, Leona lewis lives in Hackney with her boyfriend, Lou Al-Chamaa, who is an electrician by profession. They grew up in the same street and have known each other since Leona lewis was nine years old. Based on reports, they have rented a £120,000 flat together in North London and have exchanged commitment rings. Leona lewis has stated that she has made plans to marry Lou Al-Chamaa in the near future. Since she was 12 years old, Leona lewis has been a vegetarian and in the year 2008, she won PETA's Sexiest Vegetarian with Anthony Kiedis, the frontman for Red Hot Chili Peppers.
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